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miamizsun

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Location: (3261.3 Miles SE of RP)
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Posted: Jan 16, 2018 - 4:23am

Gene Therapy Had a Breakthrough 2017—2018 May Be Even Better

Gene therapy had a hell of a 2017. After decades of promises but failed deliveries, last year saw the field hitting a series of astonishing home runs.

The concept of gene therapy is elegant: like computer bugs, faulty letters in the human genome can be edited and replaced with healthy ones.

But despite early enthusiasm, the field has suffered one setback after another. At the turn of the century, the death of an 18-year-old patient with inherited liver disease after an experimental gene therapy treatment put the entire field into a deep freeze.

But no more. Last year marked the birth of gene therapy 2.0, in which the experimental dream finally became a clinical reality. Here’s how the tech grew into its explosive potential—and a sneak peek at what’s on the horizon for 2018.

1. Bad Blood, Meet CAR-T

It sounds like magic: you harvest a patient’s own immune cells, dose them with an injection of extra genetic material, and turn them into living cancer-hunting machines.

But in 2017, the FDA approved a double whammy of CAR-T immunotherapies. The first, green-lighted in August, helps kids and young adults battle an especially nasty form of leukemia called B-cell acute lymphoblastic leukemia. Two months later, a therapy for adults with non-Hodgkin lymphoma hit the scene.

Together, these approvals marked the long-anticipated debut of gene therapy in the US market. Previously, Europe has led the charge with its approval of Glybera in 2015, a gene therapy that reduces fatty acid buildup in the bloodstream.

The historic nod of confidence for CAR-T has already sparked widespread interest among academics and drug companies alike at finding new targets for the upgraded immune cells (the “T” in “CAR-T” stands for T-cell, a type of immune cell). CAR-T is especially exciting for the cancer field because it helps people who don’t respond to other classic treatments, such as chemotherapy.

Already in the works are treatments that target multiple myeloma, which causes multiple tumors in the bone or soft tissue, and glioblastoma, an aggressive brain tumor for which there is no cure.

But the technology’s potential is hardly limited to cancer. Last year, a preliminary study in two monkeys showed that genetically engineered stem cells can suppress and even eradicate HIV infections. The study, though small, tantalizingly suggests a whole new way to battle HIV after three decades of fruitless search for a vaccine. With multiple CAR-T therapies going through the pipeline, 2018 may very likely welcome new members onto the gene therapy scene.



more here...




miamizsun

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Posted: Jan 11, 2018 - 9:26am

a new cancer xprize...{#Cheers}

The Future of Cancer Treatment Is Personalized and Collaborative

Just a few years ago, microscopes were the primary tool used in cancer diagnoses, but we’ve come a long way since.

“We still look at a microscope, we still look at what organ the cancer started in,” Wender said. “But increasingly we’re looking at the molecular signature. It’s not just the genomics, and it’s not just the genes. It’s also the cellular environment around that cancer. We’re now targeting our therapies to the mutations that are found in that particular cancer.”

Cancer treatments in the past have been largely reactionary, but they don’t need to be. Most cancer is genetic, which means that treatment can be preventative. This is one reason why newer cancer treatment techniques are searching for actionable targets in the specific gene before the cancer develops.

When asked how artificial intelligence and machine learning technologies are reshaping clinical trials, Wender acknowledged that how clinical trials have been run in the past won’t work moving forward.

“Our traditional ways of learning about cancer were by finding a particular cancer type and conducting a long clinical trial that took a number of years enrolling patients from around the country. That is not how we’re going to learn to treat individual patients in the future.”

Instead, Wender emphasized the need for gathering as much data as possible, and from as many individual patients as possible. This data should encompass clinical, pathological, and molecular data and should be gathered from a patient all the way through their final outcome. “Literally every person becomes a clinical trial of one,” Wender said.

For the best cancer treatment and diagnostics, Wender says the answer is to make the process collaborative by pulling in resources from organizations and companies that are both established and emerging.

It’s no surprise to hear that the best solutions come from pairing together uncommon partners to innovate.


miamizsun

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Location: (3261.3 Miles SE of RP)
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Posted: Jan 9, 2018 - 6:43am

it's part of moving forward...

New Research Suggests Immunity to CRISPR Gene Editing Poses a Challenge

The issue arises in how the Cas9 proteins researchers use are manufactured.

The authors of the study noted that the most widely-used versions of the protein are extracted from the bacteria Staphylococcus aureus (S. aureus) and Streptococcus pyogenes (S. pyogenes). In bioengineering, particular bacteria—usually selected for being widely available and easy to cultivate—are often used to synthesize particular proteins. For example, most of our medical insulin is made from genetically modified E. coli. The researchers behind the study questioned whether because S. aureus and S. pyogenes regularly infect humans we might have built up some resistance to their proteins already. The infections they cause, often called strep and staph, are widespread enough that most people can be expected to have been exposed to the bacteria.

The study discovered that in many cases, human immune systems produced T-cells that specifically responded to the Cas9 protein from Staphylococcus aureus. This suggests that attempts at therapeutic use would cause an adaptive immune response that might render the therapy ineffective. Indeed, the authors of the paper wrote that use of these proteins in those who’ve been exposed to this bacteria could be harmful. “It may even result in significant toxicity to patients,” according to Stanford University’s Matthew Porteus, a  senior author of the paper. A paper by Wei Leong Chew suggests, “If left unchecked…it could lead to mortality.”

The authors of the paper wanted to ensure immune issues weren’t overlooked. “Like any new technology, you want to identify potential problems and engineer solutions for them,” according to Porteus. “And I think that’s where we’re at. This is an issue that should be addressed.”

But this is far from the end for CRISPR.


miamizsun

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Posted: Jul 23, 2017 - 8:13am

 NoEnzLefttoSplit wrote:

I love this guy's optimism and to his credit, a lot of what he talks about has already come to pass. In my own life, I ditched my car as it cost me $400 a month and I mainly used it to cart my empty wine bottles to the recycling bin and generate parking fines.. it was pretty good at that. Now I zip around in an electric Smart or Mercedes B 250 e (Tesla technology) as part of the local car-sharing scheme for about 20% of the cost. ... for example.

More interesting is the point touched on at the very end.. he talks about what it means to be human and that this will get more and more teased out (of the fabric of being I guess)  as human labor becomes redundant - when work no longer marks your place in society and most of the essentials are free. This was discussed by Marx (that line about going fishing in the afternoon once the means of production become common property and you no longer have to sell your labor, etc.). Heidegger also talked about it, but saw work more as the essential mode of being, bit like Camus's Sisyphos.. finding oneself in the activity of work.. which might be something to do with our nature, we are all just frenetic primates when it comes down to it and we need to play around with sticks.

This is where it gets really interesting. What is it that makes us happy? Individually? As a family? As a society? Personally I think I would fail miserably if I didn't have the feeling of mastering existential challenges (scraping enough together to pay the tax bill etc.). But maybe I'm already a relic of a bygone age.
 

you're only a relic if you're using linear thought and looking in the rear view mirror {#Wink}

let's look forward to what is coming at an ever increasing pace

the short answer is that we're naturally linear thinkers but we're living in a world of exponential growth technology

linear thought has served us well and will continue to do so (where it applies)

peter's six d's help us get a grasp on the framework of what's happening but more importantly the speed at which it is happening

there's a reason that some of the brightest people in the world are working/collaborating with the SU team and others that understand the concept

it's naturally difficult at first for most people to fathom such things (if you take some time there's a lot of examples in their material-companies that got left in the dust, etc.)

===========================================================================================

the philosophical challenge (or you could say scientific challenge socially) is where humanity will make or break the future

the evidence to me is clear that things are getting much better and that an extraordinary leap forward is in progress

imagine three broad categories of science

physical action, biological action and human action

it's very obvious that we've made great strides in the physical and that we are making great strides in the biological (digitizing biology)

however we're way behind or have been somewhat stuck in the human action branch

solution? apply the scientific method to human action (see jay snelson's book on amazon)

it would quickly solve the grand challenges we face but at what cost?

politics would have to do a 180 and we would have to radically change from war to peace

if you pm me an email that can handle lager attachments i'd gladly send you some great material that goes into some detail

enjoy your day/evening  {#Cheers}



NoEnzLefttoSplit
Being Norwegian is over-rated.
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Posted: Jul 23, 2017 - 1:46am

 miamizsun wrote:
interesting and broad overview of what he sees...

 
I love this guy's optimism and to his credit, a lot of what he talks about has already come to pass. In my own life, I ditched my car as it cost me $400 a month and I mainly used it to cart my empty wine bottles to the recycling bin and generate parking fines.. it was pretty good at that. Now I zip around in an electric Smart or Mercedes B 250 e (Tesla technology) as part of the local car-sharing scheme for about 20% of the cost. ... for example.

More interesting is the point touched on at the very end.. he talks about what it means to be human and that this will get more and more teased out (of the fabric of being I guess)  as human labor becomes redundant - when work no longer marks your place in society and most of the essentials are free. This was discussed by Marx (that line about going fishing in the afternoon once the means of production become common property and you no longer have to sell your labor, etc.). Heidegger also talked about it, but saw work more as the essential mode of being, bit like Camus's Sisyphos.. finding oneself in the activity of work.. which might be something to do with our nature, we are all just frenetic primates when it comes down to it and we need to play around with sticks.

This is where it gets really interesting. What is it that makes us happy? Individually? As a family? As a society? Personally I think I would fail miserably if I didn't have the feeling of mastering existential challenges (scraping enough together to pay the tax bill etc.). But maybe I'm already a relic of a bygone age.


miamizsun

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Location: (3261.3 Miles SE of RP)
Gender: Male


Posted: Jul 22, 2017 - 2:17pm

interesting and broad overview of what he sees...



miamizsun

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Gender: Male


Posted: Jun 28, 2017 - 8:14am

in spite of political hindrance the world is getting better

much, much better in a big way

the speed of expotech is amazing

xprize

singularity hub


miamizsun

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Gender: Male


Posted: May 28, 2017 - 6:26am

there's a really good story here,,,


SeriousLee

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Location: Dans l'milieu d'deux milles livres


Posted: May 26, 2017 - 12:40pm

 miamizsun wrote:


 
Software creating software. That can be scary. Look where humans creating humans brought us after all these ages.
miamizsun

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Posted: May 26, 2017 - 12:27pm


miamizsun

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Gender: Male


Posted: May 26, 2017 - 12:22pm


miamizsun

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Posted: Apr 10, 2017 - 1:25pm

damn interesting and worth your time


 
miamizsun

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Gender: Male


Posted: Feb 1, 2017 - 2:49pm


miamizsun

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Location: (3261.3 Miles SE of RP)
Gender: Male


Posted: Feb 1, 2017 - 6:51am

medical tricorder?

a first rev

eventually a microchip/microsensor?

eventually implantable?

i'd say so



miamizsun

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Location: (3261.3 Miles SE of RP)
Gender: Male


Posted: Dec 19, 2016 - 5:46am

good little talk in nz about expo growth

and if you think about it, the superfast growth in tech (both physical and biological) just drives home the need for us to incorporate the human action sciences asap

your personal operating system/philosophy really matters

please incentivize peace whenever and wherever possible

enjoy


miamizsun

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Gender: Male


Posted: Nov 27, 2015 - 4:58am

great talk

exciting stuff



miamizsun

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Gender: Male


Posted: Sep 30, 2015 - 6:46am

A $20 Million global competition to develop breakthrough technologies that will convert CO2 emissions from power plants and industrial facilities into valuable products like building materials, alternative fuels and other items that we use every day.

http://carbon.xprize.org




miamizsun

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Location: (3261.3 Miles SE of RP)
Gender: Male


Posted: Apr 7, 2015 - 2:49pm

design is everything?


NoEnzLefttoSplit
Being Norwegian is over-rated.
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Posted: Apr 3, 2015 - 11:14am

 ScottFromWyoming wrote:

Interesting but I stopped really paying attention when he used Kodak as an example. Kodak built the first digital camera, so no one was deceived by the importance of digital cameras and the dismal future for film... except Kodak. 

 
.. and I still don't have a yacht. fuggit. 

is there anyone else here who doesn't actually feel any richer than they were as kids in the 60s or 70s?

 
ScottFromWyoming
I eat pints
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Location: Powell
Gender: Male
Zodiac: Pisces
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Posted: Apr 3, 2015 - 11:08am

 miamizsun wrote:
Got a minute? The 6 D's of Exponentials


 
Interesting but I stopped really paying attention when he used Kodak as an example. Kodak built the first digital camera, so no one was deceived by the importance of digital cameras and the dismal future for film... except Kodak. 
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