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Hello from France - haresfur - Sep 20, 2021 - 4:13pm
 
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Recommended documentaries - Ohmsen - Sep 19, 2021 - 11:37am
 
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what the hell, miamizsun? - oldviolin - Sep 18, 2021 - 8:59am
 
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SFW & Gluttony Pants - miamizsun - Sep 17, 2021 - 4:50am
 
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Military Matters - R_P - Sep 16, 2021 - 5:02pm
 
New Music - R_P - Sep 16, 2021 - 12:59pm
 
Joe Biden - Red_Dragon - Sep 16, 2021 - 11:54am
 
All Dogs Go To Heaven - Dog Pix - Prodigal_SOB - Sep 16, 2021 - 10:12am
 
The Dragons' Roost - GeneP59 - Sep 16, 2021 - 9:59am
 
Radio Paradise NFL Pick'em Group - Proclivities - Sep 16, 2021 - 9:43am
 
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Spambags on RP - Steely_D - Sep 16, 2021 - 3:36am
 
Are you ready for some football? - Red_Dragon - Sep 15, 2021 - 4:18pm
 
Star Trek - miamizsun - Sep 15, 2021 - 3:07pm
 
COVID and China's Influence - coding_to_music - Sep 15, 2021 - 12:43pm
 
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COVID lockdowns and mandates - coding_to_music - Sep 15, 2021 - 12:23pm
 
COVID notable people - coding_to_music - Sep 15, 2021 - 12:21pm
 
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Cryptic Posts - Leave Them Guessing - oldviolin - Sep 15, 2021 - 10:12am
 
Album recommendation for fans of pop music - Proclivities - Sep 15, 2021 - 9:40am
 
Let's build a city - Red_Dragon - Sep 15, 2021 - 8:46am
 
Best of George Carlin - Jonathon - Sep 15, 2021 - 8:34am
 
*** PUNS *** PINK FLOYD - coding_to_music - Sep 14, 2021 - 9:49pm
 
Little known information...maybe even facts - haresfur - Sep 14, 2021 - 6:59pm
 
Things for which you would sell ManBird's soul - haresfur - Sep 14, 2021 - 4:27pm
 
Fox Spews - R_P - Sep 14, 2021 - 2:16pm
 
But Why? - Manbird - Sep 14, 2021 - 2:12pm
 
Looking back - Ohmsen - Sep 14, 2021 - 10:29am
 
Baseball, anyone? - ScottFromWyoming - Sep 14, 2021 - 10:06am
 
TV shows you watch - Ohmsen - Sep 14, 2021 - 9:32am
 
Florida - sunybuny - Sep 14, 2021 - 8:20am
 
Index » Internet/Computer » The Web » Tech & Science Page: 1, 2, 3 ... 193, 194, 195  Next
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miamizsun

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Location: (3261.3 Miles SE of RP)
Gender: Male


Posted: Aug 24, 2021 - 7:19pm

Surprise! Our Bodies Have Been Hiding a Trojan Horse for Gene Therapy

Nature hides astonishing medical breakthroughs.

Take CRISPR, the transformative gene editing tool. It was inspired by a lowly bacterial immune defense system and co-opted to edit our genes to treat inherited diseases, bolster cancer treatments, or even extend lifespan. Now, Dr. Feng Zhang, one of the pioneers of CRISPR, is back with another creation that could unleash the next generation of gene therapy and RNA vaccines. Only this time, his team looked deep inside our own bodies.

Powerful as they are, DNA and RNA therapeutics need to hitch a ride into our cells to work. Scientists usually call on viral vectors—delivery vehicles made from safe viruses—or lipid nanoparticles, little blobs of protective fat, to encapsulate new genetic material and tunnel into cells.

The problem? Our bodies aren’t big fans of foreign substances—particularly ones that trigger an undesirable immune response. What’s more, these delivery systems aren’t great with biological zip codes, often swarming the entire body instead of focusing on the treatment area. These “delivery problems” are half the battle for effective genetic medicine with few side effects.

“The biomedical community has been developing powerful molecular therapeutics, but delivering them to cells in a precise and efficient way is challenging,” said Zhang at the Broad Institute, the McGovern Institute, and MIT.

Enter SEND. The new delivery platform, described in Science, dazzles with its sheer ingenuity. Rather than relying on foreign carriers, SEND (selective endogenous encapsidation for cellular delivery) commandeers human proteins to make delivery vehicles that shuttle in new genetic elements. In a series of tests, the team embedded RNA cargo and CRISPR components inside cultured cells in a dish. The cells, acting as packing factories, used human proteins to encapsulate the genetic material, forming tiny balloon-like vessels that can be collected as a treatment.

Even weirder, the source of these proteins relies on viral genes domesticated eons ago by our own genome through evolution. Because the proteins are essentially human, they’re unlikely to trigger our immune system.

Although the authors only tried one packaging system, far more are hidden in our genomes. “That’s what’s so exciting,” said study author Dr. Michael Segel, adding that the system they used isn’t unique; “There are probably other RNA transfer systems in the human body that can also be harnessed for therapeutic purposes.”





miamizsun

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Location: (3261.3 Miles SE of RP)
Gender: Male


Posted: Aug 16, 2021 - 7:19am

want to see how technology is progressing?
check out this weekly round up of news



This Week’s Awesome Tech Stories From Around the Web




Red_Dragon

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Posted: Aug 11, 2021 - 4:06pm

Ohmsen

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Gender: Male


Posted: Aug 10, 2021 - 1:18pm

 Red_Dragon wrote:
Would Alejandro Jodorowski be a spiritual father to this?


Red_Dragon

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Posted: Aug 10, 2021 - 12:45pm

Part Terminator, part Tremors: This robotic worm can swim through sand
Ohmsen

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Posted: Aug 4, 2021 - 12:16pm

 black321 wrote:
just in case someone didnt see it the first time.


black321

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Location: An earth without maps
Gender: Male


Posted: Aug 4, 2021 - 11:41am

 Ohmsen wrote:





just in case someone didnt see it the first time.
Ohmsen

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Gender: Male


Posted: Aug 4, 2021 - 11:39am

 black321 wrote:

Astronomers Spot Light From Behind a Black Hole for the First Time – Proving Einstein Right Again



When doing astronomy, you can’t blink, because the difference between a never-before-seen phenomenon, and just a regular day at the telescope can be as small as seeing faint X-rays turn into fainter X-rays for a short moment.

That’s what happened when astrophysicist Dan Wilkins noticed, upon fixing his telescopes on the supermassive blackhole at the center of the galaxy I Zwicky, that following a normal series of powerful X-rays being flung out from the center, came unexpected additional flashes of X-rays that were smaller, later, and of different “colors.”

What he was observing meant astronomers got to say something they love to say: It proved Einstein right… again.


https://www.goodnewsnetwork.or...

 Red_Dragon wrote:

black321

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Location: An earth without maps
Gender: Male


Posted: Aug 4, 2021 - 11:09am


Astronomers Spot Light From Behind a Black Hole for the First Time – Proving Einstein Right Again



When doing astronomy, you can’t blink, because the difference between a never-before-seen phenomenon, and just a regular day at the telescope can be as small as seeing faint X-rays turn into fainter X-rays for a short moment.

That’s what happened when astrophysicist Dan Wilkins noticed, upon fixing his telescopes on the supermassive blackhole at the center of the galaxy I Zwicky, that following a normal series of powerful X-rays being flung out from the center, came unexpected additional flashes of X-rays that were smaller, later, and of different “colors.”

What he was observing meant astronomers got to say something they love to say: It proved Einstein right… again.


https://www.goodnewsnetwork.or...



R_P

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Posted: Aug 4, 2021 - 10:43am

Learning to Live in Steven Weinberg’s Pointless Universe
The late physicist’s most infamous statement still beguiles scientists and vexes believers
Steven Weinberg, who died last week at the age of 88, was not only a Nobel laureate physicist but also one of the most eloquent science writers of the last half century. His most famous (or perhaps infamous) statement can be found on the second-to-last page of his first popular book, The First Three Minutes, published in 1977. Having told the story of how our universe came into being with the big bang some 13.8 billion years ago, and how it may end untold billions of years in the future, he concludes that whatever the universe is about, it sure as heck isn’t about us. “The more the universe seems comprehensible,” he wrote, “the more it also seems pointless.”


(...)

As science and religion began to go their separate ways—a process that accelerated with the work of Darwin—science became secular. “The elimination of God-talk from scientific discourse,” writes historian Jon Roberts, “constitutes the defining feature of modern science.” Weinberg would have agreed. As he told an audience in 1999: “One of the great achievements of science has been, if not to make it impossible for intelligent people to be religious, then at least to make it possible for them not to be religious. We should not retreat from that accomplishment.”

Red_Dragon

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Posted: Jul 28, 2021 - 3:42pm

Astronomers detect light from behind a black hole for the first time
GeneP59

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Location: On the edge of tomorrow looking back at yesterday.
Gender: Male


Posted: Jul 18, 2021 - 1:50pm

 Red_Dragon wrote:
Aye Captain! we tried shoving a wiener in the warp drive. 
Red_Dragon

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Posted: Jul 18, 2021 - 9:01am

Star Trek’s Warp Drive Leads to New Physics
Red_Dragon

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Posted: Jun 12, 2021 - 7:30am

Major Scientific Leap: Quantum Microscope Created That Can See the Impossible
R_P

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Posted: May 6, 2021 - 11:48pm

New Study Deconstructs Dunbar’s Number: Yes, You Can Have More Than 150 Friends
miamizsun

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Location: (3261.3 Miles SE of RP)
Gender: Male


Posted: Apr 19, 2021 - 7:48am

crispr gets an on/off switch? 

Genome-wide programmable transcriptional memory by CRISPR-based epigenome editing



THE EXPERT’S TAKE:
“In an article in Cell, Nuñez and colleagues introduce CRISPRoff, a CRISPR-based programmable epigenetic memory writer protein. Unlike previous CRISPR approaches, it reliably alters a cell’s epigenetics and is capable of making changes to gene expression that are highly specific, stable, and heritable. CRISPRoff can target most genes (and more than one at a time), where this genome-wide silencing is reproducible and precise. Moreover, epigenetic memories made by CRISPRoff are reversible with CRISPRon, a multi-partite epigenetic editor. Future work includes fine-tuning the gene silencing activity by designing optimal single guide RNAs for CRISPRoff (rather than those designed for a previous system) and better characterization of the parameters relating to the stability of programmed epigenetic memory. With the ability to make such controlled changes to almost any part of the genome, scientists now have a new tool to explore the function of the genome.”


Tina Hu-Seliger, Ph.D.
Elysium Health Director of Bioinformatics




R_P

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Posted: Apr 10, 2021 - 2:37pm

Muon magnetism could hint at a breakdown of physics’ standard model
A highly anticipated measurement strengthens the case that muons behave unexpectedly
miamizsun

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Location: (3261.3 Miles SE of RP)
Gender: Male


Posted: Apr 8, 2021 - 5:52pm

this is weird, but the potential is amazing

as the video goes on pager plays mind pong

R_P

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Posted: Apr 3, 2021 - 2:15pm

Beauty filters are changing the way young girls see themselves
The most widespread use of augmented reality isn’t in gaming: it’s the face filters on social media. The result? A mass experiment on girls and young women.
Ohmsen

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Gender: Male


Posted: Mar 27, 2021 - 5:30am


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